Q. Sezary syndrome progress to?
ans.Cutaneous T-cell lymphoma.
Sézary syndrome and mycosis fungoides are T-cell lymphomas whose primary manifestation is in the skin. The disease's origin is a peripheral CD4+ T-lymphocyte, although rarer CD8+/CD4- cases have been observed. Epidermotropism by neoplastic CD4+ lymphocytes with the formation of Pautrier's microabscesses is the hallmark sign of the disease. The dominant symptoms of the disease are:
Generalized erythroderma
Lymphadenopathy
Atypical T-cells ("Sézary cells") in the peripheral blood
Hepatosplenomegaly
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